Drug interactions
Gliclazide + Maprotiline
Severity: Minor
Gliclazide and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants of the tricyclic type may enhance blood glucose lowering in patients taking sulfonylureas. Hypoglycemia is possible but uncommon, and warning symptoms may be less noticeable.
What this interaction means in plain words
Gliclazide and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Possible additive effect on glucose lowering; the mechanism is not well established.
What to do
Monitor blood glucose when maprotiline is started or stopped. Lower the gliclazide dose if hypoglycemia appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Gliclazide with Maprotiline?
MediHelp rates the interaction as minor. Gliclazide and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants of the tricyclic type may enhance blood glucose lowering in patients taking sulfonylureas. Hypoglycemia is possible but uncommon, and warning symptoms may be less noticeable.
How serious is the interaction between Gliclazide and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when maprotiline is started or stopped. Lower the gliclazide dose if hypoglycemia appears.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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