Drug interactions
Gliclazide + Mesalamine
Severity: Minor
Gliclazide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine is a salicylate derivative, but at usual doses systemic exposure is low and salicylate-type effects on sulfonylureas are unlikely. Any enhancement of gliclazide's effect would be expected only with large systemic salicylate doses.
What this interaction means in plain words
Gliclazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical displacement of gliclazide from plasma proteins and additive glucose lowering by salicylate, which is limited with mesalamine.
What to do
No routine change is needed. Monitor blood glucose if high-dose mesalamine is used in a patient with poorly controlled diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Mesalamine
Frequently asked questions
Can I take Gliclazide with Mesalamine?
MediHelp rates the interaction as minor. Gliclazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine is a salicylate derivative, but at usual doses systemic exposure is low and salicylate-type effects on sulfonylureas are unlikely. Any enhancement of gliclazide's effect would be expected only with large systemic salicylate doses.
How serious is the interaction between Gliclazide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood glucose if high-dose mesalamine is used in a patient with poorly controlled diabetes.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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