Drug interactions
Gliclazide + Nadolol
Severity: Moderate
Gliclazide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-selective beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from it. They can also modestly impair glycemic control. Sweating is usually preserved.
What this interaction means in plain words
Gliclazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade suppresses the counter-regulatory response and hypoglycemia symptoms, and inhibits glycogenolysis.
What to do
Monitor blood glucose more often and counsel the patient that sweating may be the main warning sign. Use a cardioselective beta blocker if one is clinically suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Gliclazide with Nadolol?
MediHelp rates the interaction as moderate. Gliclazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-selective beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from it. They can also modestly impair glycemic control. Sweating is usually preserved.
How serious is the interaction between Gliclazide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and counsel the patient that sweating may be the main warning sign. Use a cardioselective beta blocker if one is clinically suitable.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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