Drug interactions
Gliclazide + Nizatidine
Severity: Minor
Gliclazide and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
H2-receptor antagonists may modestly increase the absorption or effect of some sulfonylureas, and hypoglycemia has been reported with this class. With gliclazide the effect is small and uncommon.
What this interaction means in plain words
Gliclazide and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Possible increased sulfonylurea absorption from raised gastric pH; the mechanism is not well established for gliclazide.
What to do
No dose change is usually required. Monitor blood glucose when nizatidine is started in patients prone to hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Gliclazide with Nizatidine?
MediHelp rates the interaction as minor. Gliclazide and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. H2-receptor antagonists may modestly increase the absorption or effect of some sulfonylureas, and hypoglycemia has been reported with this class. With gliclazide the effect is small and uncommon.
How serious is the interaction between Gliclazide and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor blood glucose when nizatidine is started in patients prone to hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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