Drug interactions
Gliclazide + Oxaprozin
Severity: Minor
Gliclazide and Oxaprozin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. Oxaprozin is highly protein bound, and the evidence for a clinically important effect is limited.
What this interaction means in plain words
Gliclazide and Oxaprozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement or altered clearance; mechanism not clearly established.
What to do
Monitor blood glucose when oxaprozin is started and reduce gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Gliclazide with Oxaprozin?
MediHelp rates the interaction as minor. Gliclazide and Oxaprozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may potentiate the glucose-lowering effect of sulfonylureas, with occasional hypoglycemia. Oxaprozin is highly protein bound, and the evidence for a clinically important effect is limited.
How serious is the interaction between Gliclazide and Oxaprozin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when oxaprozin is started and reduce gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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