Drug interactions
Gliclazide + Prednisone
Severity: Moderate
Gliclazide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisone raises blood glucose and can offset the effect of gliclazide. Hyperglycemia can be significant with higher doses or prolonged courses, and hypoglycemia can follow dose reduction.
What this interaction means in plain words
Gliclazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose frequently during steroid therapy and increase gliclazide or add insulin if needed. Reduce the antidiabetic dose as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Gliclazide with Prednisone?
MediHelp rates the interaction as moderate. Gliclazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisone raises blood glucose and can offset the effect of gliclazide. Hyperglycemia can be significant with higher doses or prolonged courses, and hypoglycemia can follow dose reduction.
How serious is the interaction between Gliclazide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during steroid therapy and increase gliclazide or add insulin if needed. Reduce the antidiabetic dose as the steroid is tapered.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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