Drug interactions
Gliclazide + Quetiapine
Severity: Moderate
Gliclazide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is associated with weight gain, insulin resistance and hyperglycemia, which can worsen glycemic control in diabetic patients taking gliclazide.
What this interaction means in plain words
Gliclazide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired insulin secretion.
What to do
Monitor blood glucose and HbA1c after starting quetiapine and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Gliclazide with Quetiapine?
MediHelp rates the interaction as moderate. Gliclazide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is associated with weight gain, insulin resistance and hyperglycemia, which can worsen glycemic control in diabetic patients taking gliclazide.
How serious is the interaction between Gliclazide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting quetiapine and adjust the antidiabetic regimen as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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