Drug interactions
Gliclazide + Rifapentine
Severity: Moderate
Gliclazide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic enzymes and may lower gliclazide exposure, reducing its glucose-lowering effect. Loss of glycemic control is possible during treatment.
What this interaction means in plain words
Gliclazide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP2C9 and CYP2C19 increases gliclazide metabolism.
What to do
Monitor blood glucose during and after rifapentine therapy and adjust gliclazide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Gliclazide with Rifapentine?
MediHelp rates the interaction as moderate. Gliclazide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces hepatic enzymes and may lower gliclazide exposure, reducing its glucose-lowering effect. Loss of glycemic control is possible during treatment.
How serious is the interaction between Gliclazide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after rifapentine therapy and adjust gliclazide dose as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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