Drug interactions
Gliclazide + Ritonavir
Severity: Moderate
Gliclazide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can cause insulin resistance and hyperglycemia, and its mixed enzyme inhibition and induction may alter gliclazide levels unpredictably. Glycemic control may therefore worsen or fluctuate.
What this interaction means in plain words
Gliclazide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance plus variable CYP effects on gliclazide metabolism.
What to do
Monitor blood glucose closely when starting or stopping ritonavir and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Gliclazide with Ritonavir?
MediHelp rates the interaction as moderate. Gliclazide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can cause insulin resistance and hyperglycemia, and its mixed enzyme inhibition and induction may alter gliclazide levels unpredictably. Glycemic control may therefore worsen or fluctuate.
How serious is the interaction between Gliclazide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping ritonavir and adjust antidiabetic therapy accordingly.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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