Drug interactions
Gliclazide + Sulindac
Severity: Moderate
Gliclazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance sulfonylurea effect and increase the risk of hypoglycemia. Sulindac is thought to have a smaller effect than other NSAIDs, but cases of enhanced hypoglycemia cannot be excluded.
What this interaction means in plain words
Gliclazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible mechanisms include displacement from protein binding, reduced renal prostaglandin-mediated clearance and prostaglandin effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping sulindac and reduce the gliclazide dose if hypoglycemia occurs. Patients should recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Gliclazide with Sulindac?
MediHelp rates the interaction as moderate. Gliclazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance sulfonylurea effect and increase the risk of hypoglycemia. Sulindac is thought to have a smaller effect than other NSAIDs, but cases of enhanced hypoglycemia cannot be excluded.
How serious is the interaction between Gliclazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sulindac and reduce the gliclazide dose if hypoglycemia occurs. Patients should recognize hypoglycemia symptoms.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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