Drug interactions
Gliclazide + Tolfenamic acid
Severity: Moderate
Gliclazide and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate sulfonylurea hypoglycemic effect, so gliclazide could produce greater glucose lowering. The interaction is documented mainly for the class rather than for tolfenamic acid itself.
What this interaction means in plain words
Gliclazide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and reduced renal clearance, plus prostaglandin effects on insulin secretion; not firmly established.
What to do
Monitor blood glucose during co-treatment and reduce the gliclazide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Gliclazide with Tolfenamic acid?
MediHelp rates the interaction as moderate. Gliclazide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate sulfonylurea hypoglycemic effect, so gliclazide could produce greater glucose lowering. The interaction is documented mainly for the class rather than for tolfenamic acid itself.
How serious is the interaction between Gliclazide and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-treatment and reduce the gliclazide dose if hypoglycemia develops.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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