Drug interactions
Gliclazide + Tranylcypromine
Severity: Moderate
Gliclazide and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective MAO inhibitors can potentiate the hypoglycemic effects of sulfonylureas, with a risk of significant hypoglycemia. Effects may be more pronounced than with selective MAO-B inhibitors.
What this interaction means in plain words
Gliclazide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin secretion or alter glucose metabolism.
What to do
Monitor blood glucose closely when tranylcypromine is started and reduce the gliclazide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Gliclazide with Tranylcypromine?
MediHelp rates the interaction as moderate. Gliclazide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective MAO inhibitors can potentiate the hypoglycemic effects of sulfonylureas, with a risk of significant hypoglycemia. Effects may be more pronounced than with selective MAO-B inhibitors.
How serious is the interaction between Gliclazide and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when tranylcypromine is started and reduce the gliclazide dose if hypoglycemia develops.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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