Drug interactions
Gliclazide + Ziprasidone
Severity: Minor
Gliclazide and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics may worsen glucose control, which can offset the effect of gliclazide. Ziprasidone has a comparatively low metabolic liability, so the effect is usually small.
What this interaction means in plain words
Gliclazide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and altered insulin secretion may oppose the sulfonylurea effect.
What to do
Check glucose periodically after starting ziprasidone and adjust antidiabetic treatment if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Gliclazide with Ziprasidone?
MediHelp rates the interaction as minor. Gliclazide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics may worsen glucose control, which can offset the effect of gliclazide. Ziprasidone has a comparatively low metabolic liability, so the effect is usually small.
How serious is the interaction between Gliclazide and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose periodically after starting ziprasidone and adjust antidiabetic treatment if control worsens.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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