Drug interactions
Glimepiride + Imipramine
Severity: Minor
Glimepiride and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose control and may enhance the hypoglycemic effect of antidiabetic drugs. Patients may experience unexpected hypoglycemia, which can also be masked by tricyclic anticholinergic effects.
What this interaction means in plain words
Glimepiride and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Tricyclics may enhance insulin sensitivity or secretion and alter glucose homeostasis, an additive pharmacodynamic effect that is not fully characterized.
What to do
Monitor blood glucose when imipramine is started or stopped in a patient taking glimepiride. Adjust the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Imipramine?
MediHelp rates the interaction as minor. Glimepiride and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose control and may enhance the hypoglycemic effect of antidiabetic drugs. Patients may experience unexpected hypoglycemia, which can also be masked by tricyclic anticholinergic effects.
How serious is the interaction between Glimepiride and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imipramine is started or stopped in a patient taking glimepiride. Adjust the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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