Drug interactions
Glimepiride + Insulin degludec
Severity: Moderate
Glimepiride and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride with insulin has additive glucose-lowering effects and a higher risk of hypoglycemia, which may be prolonged.
What this interaction means in plain words
Glimepiride and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Additive effect: sulfonylurea-stimulated endogenous insulin release plus exogenous insulin.
What to do
Monitor blood glucose closely when starting or changing doses and reduce the glimepiride or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Insulin degludec, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Insulin degludec?
MediHelp rates the interaction as moderate. Glimepiride and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride with insulin has additive glucose-lowering effects and a higher risk of hypoglycemia, which may be prolonged.
How serious is the interaction between Glimepiride and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or changing doses and reduce the glimepiride or insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
