Drug interactions
Glimepiride + Isocarboxazid
Severity: Moderate
Glimepiride and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The risk is greatest when isocarboxazid is started or the dose is raised.
What this interaction means in plain words
Glimepiride and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion or sensitivity, but the exact mechanism is not well established.
What to do
Monitor blood glucose closely when starting or stopping isocarboxazid. Lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Isocarboxazid?
MediHelp rates the interaction as moderate. Glimepiride and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can potentiate the glucose-lowering effect of sulfonylureas and may cause hypoglycemia. The risk is greatest when isocarboxazid is started or the dose is raised.
How serious is the interaction between Glimepiride and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping isocarboxazid. Lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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