Drug interactions
Glimepiride + Ivosidenib
Severity: Moderate
Glimepiride and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9, which is the main pathway clearing glimepiride. Lower glimepiride exposure may lead to weaker glucose control and hyperglycemia.
What this interaction means in plain words
Glimepiride and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9, increasing the metabolism of glimepiride.
What to do
Monitor blood glucose and HbA1c after starting or stopping ivosidenib and increase the glimepiride dose or add another agent if control worsens. Reduce the dose again if ivosidenib is discontinued to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Glimepiride with Ivosidenib?
MediHelp rates the interaction as moderate. Glimepiride and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9, which is the main pathway clearing glimepiride. Lower glimepiride exposure may lead to weaker glucose control and hyperglycemia.
How serious is the interaction between Glimepiride and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping ivosidenib and increase the glimepiride dose or add another agent if control worsens. Reduce the dose again if ivosidenib is discontinued to avoid hypoglycemia.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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