Drug interactions
Glimepiride + Ketoconazole
Severity: Moderate
Glimepiride and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase glimepiride levels, strengthening its glucose-lowering effect and the risk of hypoglycemia.
What this interaction means in plain words
Glimepiride and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP2C9, the main enzyme metabolizing glimepiride.
What to do
Monitor blood glucose when starting or stopping ketoconazole and lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ketoconazole?
MediHelp rates the interaction as moderate. Glimepiride and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may increase glimepiride levels, strengthening its glucose-lowering effect and the risk of hypoglycemia.
How serious is the interaction between Glimepiride and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ketoconazole and lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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