Drug interactions
Glimepiride + Lisinopril
Severity: Moderate
Glimepiride and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. Hypoglycemia can occur, especially soon after starting the ACE inhibitor.
What this interaction means in plain words
Glimepiride and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity and raise bradykinin, adding to sulfonylurea action.
What to do
Monitor blood glucose closely during the first weeks of combined therapy. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Lisinopril?
MediHelp rates the interaction as moderate. Glimepiride and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. Hypoglycemia can occur, especially soon after starting the ACE inhibitor.
How serious is the interaction between Glimepiride and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the first weeks of combined therapy. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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