Drug interactions
Glimepiride + Meclofenamic acid
Severity: Moderate
Glimepiride and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is variable and more likely with highly protein-bound NSAIDs.
What this interaction means in plain words
Glimepiride and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal prostaglandin-mediated clearance, with additive effects on glucose.
What to do
Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Meclofenamic acid?
MediHelp rates the interaction as moderate. Glimepiride and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is variable and more likely with highly protein-bound NSAIDs.
How serious is the interaction between Glimepiride and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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