Drug interactions
Glimepiride + Miconazole
Severity: Moderate
Glimepiride and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride is metabolized by CYP2C9, which miconazole inhibits. Increased glimepiride exposure can cause prolonged or severe hypoglycemia. Case reports with miconazole, including vaginal and oral gel forms, support this concern.
What this interaction means in plain words
Glimepiride and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP2C9, reducing glimepiride clearance.
What to do
Advise patients to monitor blood glucose more closely and recognize hypoglycemia symptoms. Lower the sulfonylurea dose if glucose falls during miconazole use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Miconazole?
MediHelp rates the interaction as moderate. Glimepiride and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride is metabolized by CYP2C9, which miconazole inhibits. Increased glimepiride exposure can cause prolonged or severe hypoglycemia. Case reports with miconazole, including vaginal and oral gel forms, support this concern.
How serious is the interaction between Glimepiride and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose more closely and recognize hypoglycemia symptoms. Lower the sulfonylurea dose if glucose falls during miconazole use.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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