Drug interactions
Glimepiride + Moexipril
Severity: Moderate
Glimepiride and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can potentiate the hypoglycemic effect of sulfonylureas. Hypoglycemia is most likely early in combined therapy.
What this interaction means in plain words
Glimepiride and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Pharmacodynamic synergism through improved insulin sensitivity with ACE inhibition.
What to do
Monitor blood glucose after starting moexipril and reduce the glimepiride dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Moexipril?
MediHelp rates the interaction as moderate. Glimepiride and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can potentiate the hypoglycemic effect of sulfonylureas. Hypoglycemia is most likely early in combined therapy.
How serious is the interaction between Glimepiride and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting moexipril and reduce the glimepiride dose if hypoglycemia develops.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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