Drug interactions
Glimepiride + Nelfinavir
Severity: Moderate
Glimepiride and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir can induce insulin resistance and hyperglycemia, which may blunt the effect of glimepiride. Glycemic control may worsen after starting the antiretroviral.
What this interaction means in plain words
Glimepiride and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance antagonizes the glucose-lowering effect of glimepiride.
What to do
Check blood glucose regularly after nelfinavir initiation and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Glimepiride with Nelfinavir?
MediHelp rates the interaction as moderate. Glimepiride and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir can induce insulin resistance and hyperglycemia, which may blunt the effect of glimepiride. Glycemic control may worsen after starting the antiretroviral.
How serious is the interaction between Glimepiride and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose regularly after nelfinavir initiation and adjust antidiabetic therapy as needed.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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