Drug interactions
Glimepiride + Phenelzine
Severity: Moderate
Glimepiride and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAOIs can potentiate the hypoglycemic effect of sulfonylureas, increasing the risk of prolonged or severe hypoglycemia. Symptoms may be misattributed to psychiatric effects.
What this interaction means in plain words
Glimepiride and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAOIs may enhance insulin secretion and impair counter-regulation, adding to sulfonylurea-induced insulin release; the exact mechanism is not fully established.
What to do
Monitor blood glucose closely when starting, stopping or changing the MAOI. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Phenelzine?
MediHelp rates the interaction as moderate. Glimepiride and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAOIs can potentiate the hypoglycemic effect of sulfonylureas, increasing the risk of prolonged or severe hypoglycemia. Symptoms may be misattributed to psychiatric effects.
How serious is the interaction between Glimepiride and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, stopping or changing the MAOI. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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