Drug interactions
Glimepiride + Ramipril
Severity: Moderate
Glimepiride and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may augment the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, particularly soon after ramipril is started.
What this interaction means in plain words
Glimepiride and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ramipril belongs to Cardiovascular.
Why it happens
Additive glucose lowering, with ACE inhibition enhancing insulin sensitivity; the mechanism is incompletely defined.
What to do
Monitor blood glucose when ramipril is initiated or titrated, and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ramipril?
MediHelp rates the interaction as moderate. Glimepiride and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may augment the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, particularly soon after ramipril is started.
How serious is the interaction between Glimepiride and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ramipril is initiated or titrated, and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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