Drug interactions
Glimepiride-pioglitazone + Iloperidone
Severity: Moderate
Glimepiride-pioglitazone and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics may cause hyperglycemia and weight gain, potentially undermining glycemic control achieved with glimepiride and pioglitazone. Iloperidone has a relatively lower metabolic risk than some agents but monitoring remains warranted.
What this interaction means in plain words
Glimepiride-pioglitazone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and weight gain oppose antidiabetic drug effects.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Iloperidone?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics may cause hyperglycemia and weight gain, potentially undermining glycemic control achieved with glimepiride and pioglitazone. Iloperidone has a relatively lower metabolic risk than some agents but monitoring remains warranted.
How serious is the interaction between Glimepiride-pioglitazone and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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