Drug interactions
Glimepiride-pioglitazone + Letermovir
Severity: Moderate
Glimepiride-pioglitazone and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure and increase risk of hypoglycemia, edema or other dose-related effects. Letermovir may also modestly affect glimepiride (CYP2C9 induction) though the effect is minor.
What this interaction means in plain words
Glimepiride-pioglitazone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP2C8, reducing pioglitazone clearance.
What to do
Monitor blood glucose and for fluid retention; reduce the pioglitazone dose if adverse effects or hypoglycemia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Letermovir?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP2C8 and OATP1B1/3, so it may raise pioglitazone exposure and increase risk of hypoglycemia, edema or other dose-related effects. Letermovir may also modestly affect glimepiride (CYP2C9 induction) though the effect is minor.
How serious is the interaction between Glimepiride-pioglitazone and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for fluid retention; reduce the pioglitazone dose if adverse effects or hypoglycemia appear.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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