Drug interactions
Glimepiride-pioglitazone + Lurasidone
Severity: Minor
Glimepiride-pioglitazone and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can affect glucose metabolism and may reduce the effectiveness of antidiabetic therapy. Lurasidone has a relatively small metabolic impact compared with other agents in its class.
What this interaction means in plain words
Glimepiride-pioglitazone and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related changes in insulin resistance and beta-cell function may oppose antidiabetic effects.
What to do
Monitor blood glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Lurasidone?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can affect glucose metabolism and may reduce the effectiveness of antidiabetic therapy. Lurasidone has a relatively small metabolic impact compared with other agents in its class.
How serious is the interaction between Glimepiride-pioglitazone and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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