Drug interactions
Glimepiride-pioglitazone + Mefenamic acid
Severity: Moderate
Glimepiride-pioglitazone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may enhance the hypoglycemic effect of glimepiride. Fenamates can also affect renal function and fluid balance, which matters with pioglitazone.
What this interaction means in plain words
Glimepiride-pioglitazone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Possible CYP2C9 competition and protein-binding displacement raising glimepiride exposure, plus prostaglandin-related effects.
What to do
Monitor blood glucose and lower the glimepiride dose if hypoglycemia occurs. Limit NSAID duration and watch for edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Mefenamic acid?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may enhance the hypoglycemic effect of glimepiride. Fenamates can also affect renal function and fluid balance, which matters with pioglitazone.
How serious is the interaction between Glimepiride-pioglitazone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and lower the glimepiride dose if hypoglycemia occurs. Limit NSAID duration and watch for edema.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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