Drug interactions
Glimepiride-pioglitazone + Moxifloxacin
Severity: Moderate
Glimepiride-pioglitazone and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones including moxifloxacin can cause hypoglycemia or hyperglycemia in patients on antidiabetic drugs, particularly sulfonylureas. Moxifloxacin carries a lower risk than some other quinolones, but cases occur.
What this interaction means in plain words
Glimepiride-pioglitazone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, adding to sulfonylurea effects and causing dysglycemia.
What to do
Monitor blood glucose during moxifloxacin therapy and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if marked dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Moxifloxacin?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones including moxifloxacin can cause hypoglycemia or hyperglycemia in patients on antidiabetic drugs, particularly sulfonylureas. Moxifloxacin carries a lower risk than some other quinolones, but cases occur.
How serious is the interaction between Glimepiride-pioglitazone and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during moxifloxacin therapy and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if marked dysglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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