Drug interactions
Glimepiride-pioglitazone + Piroxicam
Severity: Moderate
Glimepiride-pioglitazone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam is highly protein bound and may potentiate the hypoglycemic action of glimepiride. Hypoglycemia may occur, especially in the elderly or with renal impairment.
What this interaction means in plain words
Glimepiride-pioglitazone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and reduced sulfonylurea clearance; not firmly established.
What to do
Monitor blood glucose when adding or stopping piroxicam and lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Piroxicam?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam is highly protein bound and may potentiate the hypoglycemic action of glimepiride. Hypoglycemia may occur, especially in the elderly or with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when adding or stopping piroxicam and lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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