Drug interactions
Glimepiride-pioglitazone + Rosuvastatin
Severity: Minor
Glimepiride-pioglitazone and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is increased rosuvastatin myopathy risk via OATP1B1 inhibition by pioglitazone. This is not an established clinically relevant interaction, and the drugs are commonly combined in diabetes care.
What this interaction means in plain words
Glimepiride-pioglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Theoretical OATP1B1 inhibition by pioglitazone; no established clinical effect.
What to do
No dose change is needed; advise patients to report unexplained muscle pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride-pioglitazone and Rosuvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Glimepiride-pioglitazone with Rosuvastatin?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is increased rosuvastatin myopathy risk via OATP1B1 inhibition by pioglitazone. This is not an established clinically relevant interaction, and the drugs are commonly combined in diabetes care.
How serious is the interaction between Glimepiride-pioglitazone and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; advise patients to report unexplained muscle pain.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
