Drug interactions
Glimepiride-pioglitazone + Tacrolimus
Severity: Minor
Glimepiride-pioglitazone and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A rise in tacrolimus levels with glimepiride has been suggested but the mechanism is not established. Tacrolimus itself can impair glucose tolerance and cause new-onset diabetes, which may be more relevant to glycemic control with these agents.
What this interaction means in plain words
Glimepiride-pioglitazone and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Mechanism not established; tacrolimus also has independent diabetogenic effects via reduced insulin secretion.
What to do
Monitor tacrolimus trough levels and blood glucose when starting or stopping glimepiride-pioglitazone, adjusting doses based on results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Tacrolimus?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A rise in tacrolimus levels with glimepiride has been suggested but the mechanism is not established. Tacrolimus itself can impair glucose tolerance and cause new-onset diabetes, which may be more relevant to glycemic control with these agents.
How serious is the interaction between Glimepiride-pioglitazone and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and blood glucose when starting or stopping glimepiride-pioglitazone, adjusting doses based on results.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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