Drug interactions
Glimepiride-pioglitazone + Tipranavir
Severity: Moderate
Glimepiride-pioglitazone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir (given with ritonavir) can alter glucose control through protease inhibitor related insulin resistance and through enzyme effects on CYP2C9 and CYP3A4 substrates. Loss of glycemic control or, less often, changes in drug exposure may occur.
What this interaction means in plain words
Glimepiride-pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitors cause insulin resistance, and tipranavir/ritonavir has mixed inhibitory and inducing effects on CYP enzymes metabolizing glimepiride and pioglitazone.
What to do
Monitor blood glucose and HbA1c after starting or stopping tipranavir and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Tipranavir?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir (given with ritonavir) can alter glucose control through protease inhibitor related insulin resistance and through enzyme effects on CYP2C9 and CYP3A4 substrates. Loss of glycemic control or, less often, changes in drug exposure may occur.
How serious is the interaction between Glimepiride-pioglitazone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping tipranavir and adjust antidiabetic doses accordingly.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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