Drug interactions
Glipizide-metformin + Glycopyrrolate
Severity: Minor
Glipizide-metformin and Glycopyrrolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate slows gastric emptying and gastrointestinal motility, which may change the absorption of oral drugs and has been reported to raise metformin exposure. The clinical significance is not well established.
What this interaction means in plain words
Glipizide-metformin and Glycopyrrolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Glycopyrrolate belongs to Respiratory.
Why it happens
Anticholinergic slowing of gastric motility may alter absorption of oral antidiabetic drugs.
What to do
Monitor blood glucose and metformin tolerability when starting glycopyrrolate and adjust the dose if adverse effects arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glipizide-metformin with Glycopyrrolate?
MediHelp rates the interaction as minor. Glipizide-metformin and Glycopyrrolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycopyrrolate slows gastric emptying and gastrointestinal motility, which may change the absorption of oral drugs and has been reported to raise metformin exposure. The clinical significance is not well established.
How serious is the interaction between Glipizide-metformin and Glycopyrrolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and metformin tolerability when starting glycopyrrolate and adjust the dose if adverse effects arise.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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