Drug interactions
Glipizide-metformin + Ketoprofen
Severity: Moderate
Glipizide-metformin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may modestly enhance glipizide's glucose-lowering effect, with a possibility of hypoglycemia. NSAID effects on renal function may also affect metformin clearance.
What this interaction means in plain words
Glipizide-metformin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement; NSAID-related reduction in renal prostaglandins may impair metformin clearance.
What to do
Monitor blood glucose and renal function when starting or stopping ketoprofen. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Glipizide-metformin with Ketoprofen?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen may modestly enhance glipizide's glucose-lowering effect, with a possibility of hypoglycemia. NSAID effects on renal function may also affect metformin clearance.
How serious is the interaction between Glipizide-metformin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or stopping ketoprofen. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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