Drug interactions
Glipizide-metformin + Nadolol
Severity: Moderate
Glipizide-metformin and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers like nadolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay recovery from low glucose. They can also modestly impair glycemic control, which matters for patients on glipizide.
What this interaction means in plain words
Glipizide-metformin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade suppresses sympathetic hypoglycemia symptoms and inhibits glycogenolysis and gluconeogenesis counterregulation.
What to do
Counsel the patient that sweating may be the main remaining warning sign, and monitor blood glucose more often. Consider a cardioselective beta-blocker if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glipizide-metformin with Nadolol?
MediHelp rates the interaction as moderate. Glipizide-metformin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers like nadolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay recovery from low glucose. They can also modestly impair glycemic control, which matters for patients on glipizide.
How serious is the interaction between Glipizide-metformin and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient that sweating may be the main remaining warning sign, and monitor blood glucose more often. Consider a cardioselective beta-blocker if clinically appropriate.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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