Drug interactions
Glipizide-metformin + Oxaprozin
Severity: Moderate
Glipizide-metformin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of sulfonylureas such as glipizide, raising the risk of hypoglycemia. NSAIDs can also impair renal function, which could affect metformin clearance.
What this interaction means in plain words
Glipizide-metformin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Possible displacement of glipizide from plasma proteins and prostaglandin-related effects on insulin secretion; the evidence is limited, and NSAID-induced renal impairment may add to metformin accumulation.
What to do
Monitor blood glucose and renal function when oxaprozin is used regularly. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Glipizide-metformin with Oxaprozin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the glucose-lowering effect of sulfonylureas such as glipizide, raising the risk of hypoglycemia. NSAIDs can also impair renal function, which could affect metformin clearance.
How serious is the interaction between Glipizide-metformin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when oxaprozin is used regularly. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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