Drug interactions
Glipizide-metformin + Prednisone
Severity: Moderate
Glipizide-metformin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as prednisone raise blood glucose by promoting hepatic gluconeogenesis and insulin resistance. This can weaken the glucose-lowering effect of glipizide and metformin and lead to loss of glycemic control, especially during higher-dose or prolonged courses.
What this interaction means in plain words
Glipizide-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced insulin resistance and increased hepatic glucose output.
What to do
Monitor blood glucose more frequently when starting, changing or stopping prednisone, and increase the antidiabetic doses as needed. Reduce doses again when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Glipizide-metformin with Prednisone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as prednisone raise blood glucose by promoting hepatic gluconeogenesis and insulin resistance. This can weaken the glucose-lowering effect of glipizide and metformin and lead to loss of glycemic control, especially during higher-dose or prolonged courses.
How serious is the interaction between Glipizide-metformin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, changing or stopping prednisone, and increase the antidiabetic doses as needed. Reduce doses again when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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