Drug interactions
Glipizide-metformin + Quetiapine
Severity: Moderate
Glipizide-metformin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may weaken the effect of antidiabetic therapy. Glycemic control may deteriorate in diabetic patients.
What this interaction means in plain words
Glipizide-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Atypical antipsychotic-associated insulin resistance and metabolic effects oppose antidiabetic therapy.
What to do
Check blood glucose and HbA1c at baseline and periodically during treatment. Intensify the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Glipizide-metformin with Quetiapine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may weaken the effect of antidiabetic therapy. Glycemic control may deteriorate in diabetic patients.
How serious is the interaction between Glipizide-metformin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose and HbA1c at baseline and periodically during treatment. Intensify the antidiabetic regimen if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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