Drug interactions
Glipizide-metformin + Quinidine
Severity: Moderate
Glipizide-metformin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may raise metformin levels by competing for renal tubular secretion. Quinidine can also cause hypoglycemia by stimulating insulin release.
What this interaction means in plain words
Glipizide-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal organic cation transporters reduces metformin clearance, and quinidine can also stimulate pancreatic insulin secretion.
What to do
Monitor blood glucose and renal function when quinidine is used with this combination. Reduce the metformin or glipizide dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Quinidine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may raise metformin levels by competing for renal tubular secretion. Quinidine can also cause hypoglycemia by stimulating insulin release.
How serious is the interaction between Glipizide-metformin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when quinidine is used with this combination. Reduce the metformin or glipizide dose if adverse effects occur.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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