Drug interactions
Glipizide-metformin + Rifapentine
Severity: Moderate
Glipizide-metformin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP enzymes including CYP2C9 and may reduce glipizide exposure. Glycemic control may worsen during therapy and hypoglycemia can occur after discontinuation.
What this interaction means in plain words
Glipizide-metformin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP2C9 increases glipizide clearance.
What to do
Monitor glucose during rifapentine and for several weeks afterward, adjusting glipizide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Rifapentine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of CYP enzymes including CYP2C9 and may reduce glipizide exposure. Glycemic control may worsen during therapy and hypoglycemia can occur after discontinuation.
How serious is the interaction between Glipizide-metformin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose during rifapentine and for several weeks afterward, adjusting glipizide dose accordingly.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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