Drug interactions
Glipizide-metformin + Ritonavir
Severity: Moderate
Glipizide-metformin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can cause insulin resistance and hyperglycemia, opposing the effect of glipizide and metformin. It also has variable effects on CYP enzymes and may change glipizide exposure unpredictably.
What this interaction means in plain words
Glipizide-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance plus mixed CYP inhibition and induction affecting glipizide metabolism.
What to do
Monitor glucose and HbA1c regularly when ritonavir is started, changed or stopped. Adjust antidiabetic doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Ritonavir?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can cause insulin resistance and hyperglycemia, opposing the effect of glipizide and metformin. It also has variable effects on CYP enzymes and may change glipizide exposure unpredictably.
How serious is the interaction between Glipizide-metformin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly when ritonavir is started, changed or stopped. Adjust antidiabetic doses based on response.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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