Drug interactions
Glipizide-metformin + Sulindac
Severity: Minor
Glipizide-metformin and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance sulfonylurea effect, with occasional hypoglycemia reported. Sulindac appears less likely to interact than other NSAIDs, so the clinical impact is generally small.
What this interaction means in plain words
Glipizide-metformin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding or prostaglandin-related effects on insulin secretion; not well established for sulindac.
What to do
Monitor blood glucose when starting or stopping sulindac. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Glipizide-metformin with Sulindac?
MediHelp rates the interaction as minor. Glipizide-metformin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may enhance sulfonylurea effect, with occasional hypoglycemia reported. Sulindac appears less likely to interact than other NSAIDs, so the clinical impact is generally small.
How serious is the interaction between Glipizide-metformin and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sulindac. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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