Drug interactions
Glipizide-metformin + Thioridazine
Severity: Moderate
Glipizide-metformin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines like thioridazine can raise blood glucose and impair control in patients on antidiabetic drugs. Glucose may fall again if the antipsychotic is withdrawn, risking hypoglycemia.
What this interaction means in plain words
Glipizide-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Thioridazine may impair insulin release and induce insulin resistance, antagonizing hypoglycemic agents.
What to do
Monitor glucose on starting thioridazine and adjust antidiabetic doses. Recheck glucose after the drug is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Thioridazine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines like thioridazine can raise blood glucose and impair control in patients on antidiabetic drugs. Glucose may fall again if the antipsychotic is withdrawn, risking hypoglycemia.
How serious is the interaction between Glipizide-metformin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose on starting thioridazine and adjust antidiabetic doses. Recheck glucose after the drug is stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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