Drug interactions
Glipizide-metformin + Tolfenamic acid
Severity: Minor
Glipizide-metformin and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate sulfonylurea-induced hypoglycemia. Tolfenamic acid may do so too, although data are limited.
What this interaction means in plain words
Glipizide-metformin and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement or inhibition of CYP2C9 metabolism of glipizide; not firmly established.
What to do
Monitor blood glucose when the NSAID is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Glipizide-metformin with Tolfenamic acid?
MediHelp rates the interaction as minor. Glipizide-metformin and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may potentiate sulfonylurea-induced hypoglycemia. Tolfenamic acid may do so too, although data are limited.
How serious is the interaction between Glipizide-metformin and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the NSAID is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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