Drug interactions
Glipizide-metformin + Tranylcypromine
Severity: Moderate
Glipizide-metformin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can intensify the glucose-lowering effect of antidiabetic drugs and lead to hypoglycemia. This is particularly relevant for the sulfonylurea component.
What this interaction means in plain words
Glipizide-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin secretion or sensitivity.
What to do
Monitor blood glucose closely when tranylcypromine is started, changed or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Tranylcypromine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can intensify the glucose-lowering effect of antidiabetic drugs and lead to hypoglycemia. This is particularly relevant for the sulfonylurea component.
How serious is the interaction between Glipizide-metformin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when tranylcypromine is started, changed or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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