Drug interactions
Glipizide-metformin + Verapamil
Severity: Minor
Glipizide-metformin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may reduce hepatic uptake of metformin, which can lessen its glucose-lowering effect. The effect is usually modest, and verapamil may also slightly worsen glucose tolerance.
What this interaction means in plain words
Glipizide-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits OCT1-mediated hepatic uptake of metformin.
What to do
Monitor glucose control when verapamil is started or stopped. Adjust the metformin dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Glipizide-metformin with Verapamil?
MediHelp rates the interaction as minor. Glipizide-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may reduce hepatic uptake of metformin, which can lessen its glucose-lowering effect. The effect is usually modest, and verapamil may also slightly worsen glucose tolerance.
How serious is the interaction between Glipizide-metformin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when verapamil is started or stopped. Adjust the metformin dose if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
