Drug interactions
Glipizide-metformin + Warfarin
Severity: Moderate
Glipizide-metformin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonylureas and warfarin may affect each other's levels through protein binding and CYP2C9 competition, so INR and glucose can shift. Changes are usually modest but can matter in unstable patients.
What this interaction means in plain words
Glipizide-metformin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding between glipizide and warfarin.
What to do
Check INR and blood glucose more often when starting or stopping either drug. Adjust warfarin or glipizide doses according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Glipizide-metformin with Warfarin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonylureas and warfarin may affect each other's levels through protein binding and CYP2C9 competition, so INR and glucose can shift. Changes are usually modest but can matter in unstable patients.
How serious is the interaction between Glipizide-metformin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR and blood glucose more often when starting or stopping either drug. Adjust warfarin or glipizide doses according to results.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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