Drug interactions
Glucagon intranasal + Glycopyrronium
Severity: Moderate
Glucagon intranasal and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics such as glycopyrronium slow gastrointestinal motility, and glucagon also inhibits gut motility. Used together they may add to constipation, bloating, nausea and other gastrointestinal adverse effects.
What this interaction means in plain words
Glucagon intranasal and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility through anticholinergic and glucagon effects.
What to do
Monitor for worsening gastrointestinal symptoms such as constipation or ileus. Use of glucagon for severe hypoglycemia should not be withheld.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon intranasal with Glycopyrronium?
MediHelp rates the interaction as moderate. Glucagon intranasal and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergics such as glycopyrronium slow gastrointestinal motility, and glucagon also inhibits gut motility. Used together they may add to constipation, bloating, nausea and other gastrointestinal adverse effects.
How serious is the interaction between Glucagon intranasal and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening gastrointestinal symptoms such as constipation or ileus. Use of glucagon for severe hypoglycemia should not be withheld.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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